Synthesis and antimicrobial activity of 4-(5-ARYL-2-FUROYL)morpholines and 4-[(5-ARYL-2-FURYL)carbonothioyl] morpholines
نویسندگان
چکیده
By the reaction of furan-2-carboxylic acids and furfural with diazonium salts 1a-j arylfuran-2-carboxylic 4a-e 5-arylfuran-2-carbaldehydes 5a-f were synthesized. Acids transformed into appropriated acylchlorides 6a-e used for preparation 4-(5-aryl-2-furoyl)morpholines 7a-e . 4-[(5-Aryl-2-furyl)carbonothioyl]morpholines 8a-f prepared from aldehydes by using Willgerodt-Kindler reaction. The structures obtained compounds confirmed 1 H NMR spectroscopy elemental analysis. All these new gave spectroscopic data in accordance proposed structures. antimicrobial activities synthesized investigated high activity against C. neoformans ATCC 208821 identified.
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ژورنال
عنوان ژورنال: ????????
سال: 2021
ISSN: ['2411-6076', '2709-135X']
DOI: https://doi.org/10.3897/pharmacia.68.e46942